Showing posts with label Levels. Show all posts
Showing posts with label Levels. Show all posts

Thursday, 15 August 2013

'Safe' levels of sugar can still be harmful to your health

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Main Category: Nutrition / Diet
Also Included In: Public Health
Article Date: 14 Aug 2013 - 10:00 PDT Current ratings for:
'Safe' levels of sugar can still be harmful to your health
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Consuming the equivalent of three cans of soda on a daily basis, or a 25% increased added-sugar intake, may decrease lifespan and reduce the rate of reproduction, according to a study of mice published in the journal Nature Communications.

Researchers from the University of Utah conducted a toxicity experiment on 156 mice, of which 58 were male and 98 were female.

The experiment involved placing them in room-sized pens called "mouse barns" with a number of nest boxes. The researchers say this allowed the mice to move around naturally to find mates and explore the territories they wished.

The mice were fed a diet of a nutritious wheat-corn-soybean mix with vitamins and minerals. But one group of mice had 25% more sugar mixed with their food - half fructose and half glucose. Mice in a control group were fed corn starch in place of the added sugars.

The National Research Council recommends that people should have no more than 25% of their daily calories from foods and beverages with added sugar.

Cans of soda drink
This study in mice suggests that consuming the equivalent of three extra sodas a day could decrease your length of life.

This is the equivalent of consuming three cans of sweetened soda a day alongside a healthy, no-added-sugar diet.

However, the US Centers for Disease Control and Prevention (CDC) issued a report this year revealing that around 13% of Americans' total daily calorie intake is from added-sugar sources.

Results of this most recent research showed that after 32 weeks in the mouse barns, 35% of the female mice who were fed the added-sugar foods died, compared with 17% of female mice fed the no-added-sugar diet.

Additionally, the results showed that male mice fed the added-sugar diet held 26% less territory compared with male mice who were fed the no-added-sugar diet.

The research also showed that male mice on the sugar diet produced 25% fewer offspring compared with the male mice in the control group.

However, the results reported no difference between the mice fed the healthy diet and those fed the added-sugar diet when looking at obesity, fasting insulin levels, fasting glucose levels and fasting triglyceride levels.

The study authors say of the findings:

"Our results provide evidence that added sugar consumed at concentrations currently considered safe exerts dramatic adverse impacts on mammalian health.

This demonstrates the adverse effects of added sugars at human-relevant levels."

The researchers add that the strength of this study is built on how the mice were tested in a natural environment they are accustomed to, providing more accurate results.

Wayne Potts, professor of biology at the University of Utah and the study's senior author, says:

"Mice happen to be an excellent mammal to model human dietary issues because they have been living on the same diet as we have ever since the agricultural revolution 10,000 years ago."

There are many types of sugars added to food and beverages, particularly sweets, chocolate, sodas and some juice drinks. These may be listed in the forms of:

GlucoseSucroseMaltoseCorn SyrupHoneyHydrolyzed starchInvert sugarFructose.

The study's authors say that this research shows there is a need for "human-made toxic substances," like those listed above, to be assessed.

They say that "the need is particularly strong for pharmaceutical science, where 73% of drugs that pass pre-clinical trials fail due to safety concerns, and for toxicology, where shockingly few compounds receive critical or long-term toxicity testing."

Prof. Potts adds:

"Our test shows an adverse outcome from the added sugar diet that could not be detected by conventional tests. You have to ask why we did not discover them 20 years ago."

"The answer is that until now, we have not had a functional, broad and sensitive test to screen the potential toxic substances that are being released into the environment or in our drugs or our food supply."

Written by Honor Whiteman


Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today Visit our nutrition / diet section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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Whiteman, Honor. "'Safe' levels of sugar can still be harmful to your health." Medical News Today. MediLexicon, Intl., 14 Aug. 2013. Web.
14 Aug. 2013. APA

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posted by sakara on 14 Aug 2013 at 1:05 pm

So far, so good for me, in my 50s, and occasionally drink a whole 2 liters of soda in one day.

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''Safe' levels of sugar can still be harmful to your health'

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Tuesday, 30 July 2013

Blocking a master switch controlling cells' response to low levels of oxygen could lead to new cancer drugs

Main Category: Cancer / Oncology
Article Date: 29 Jul 2013 - 1:00 PDT Current ratings for:
Blocking a master switch controlling cells' response to low levels of oxygen could lead to new cancer drugs
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Scientists have discovered a new molecule that prevents cancer cells from responding and surviving when starved of oxygen and which could be developed into new treatments for the disease, according to new research published in the Journal of the American Chemical Society.

Cancer Research UK scientists at the University of Southampton found that this molecule targets the master switch -- HIF-1 -- that cancer cells use to adapt to low oxygen levels, a common feature in the disease.

The researchers uncovered a way to stop cancer cells using this switch through an approach called 'synthetic biology'. By testing 3.2 million potential compounds, made by specially engineered bacteria, they were able to find a molecule that stopped HIF-1 from working.

All cells need a blood supply to provide them with the oxygen and nutrients they require to survive. Cancer tumours grow rapidly and as the tumour gets bigger it outstrips the supply of oxygen and nutrients that the surrounding blood vessels can deliver.

But, to cope with this low-oxygen environment, HIF-1 acts as a master switch that turns on hundreds of genes, allowing cancer cells to survive. HIF-1 triggers the formation of new blood vessels around tumours, causing more oxygen and nutrients to be delivered to the starving tumour, which in turn allows it to keep growing.

Dr Ali Tavassoli, a Cancer Research UK scientist whose team discovered and developed the compound at the University of Southampton, said: "We've found a way to target the steps that cancer cells take to survive and we hope that our research will one day lead to effective drugs that can stop cancers adapting to a low oxygen environment, stopping their growth. The next step is to further develop this molecule to create an effective treatment."

Dr Julie Sharp, senior science information manager at Cancer Research UK, said: "Finding ways to disrupt the tools that cancer cells use to adapt and grow when starved of oxygen has been a hot topic in cancer research, but finding drugs that do this effectively has proved elusive.

"For the first time our scientists have found a way to block a master switch controlling cells response to low levels of oxygen -- an important step towards creating drugs that could halt cancer in its tracks."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our cancer / oncology section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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University of Southampton. "Blocking a master switch controlling cells' response to low levels of oxygen could lead to new cancer drugs." Medical News Today. MediLexicon, Intl., 29 Jul. 2013. Web.
29 Jul. 2013. APA

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'Blocking a master switch controlling cells' response to low levels of oxygen could lead to new cancer drugs'

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View the original article here

Friday, 26 July 2013

High levels of a specific enzyme in mice fetuses linked to anxiety

Main Category: Anxiety / Stress
Also Included In: Depression;  Neurology / Neuroscience
Article Date: 25 Jul 2013 - 2:00 PDT Current ratings for:
High levels of a specific enzyme in mice fetuses linked to anxiety
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Mouse embryos with the human enzyme CYP2C19 in the brain develop a smaller hippocampus and anxiety-like behaviour as adults. The results of this new study, which is published in the journal Molecular Psychiatry, agree in principle with earlier genetic findings in humans, and can improve science's understanding of the genetic factors behind depression and anxiety disorders and contribute to the development of new anti-anxiety drugs.

Scientists have long been searching for the genetic reasons for the great differences in sensitivity that people show towards depression and anxiety disorders. Now, researchers at Karolinska Institutet in Sweden have taken a closer look at the CYP2C19 enzyme, which plays an important part in the liver metabolism of psychoactive substances, such as antidepressants (e.g. SSRI drugs). CYP2C19 also operates on endogenous substances that affect the central nervous system. Interestingly, there is a genetic variation between humans, since mutations of the CYP2C19 gene leave people with no, low, normal or high levels of the enzyme.

The present study was conducted on transgenic mice, which had copies of the human CYP2C19 gene inserted into their DNA so that the researchers could examine if the expression of CYP2C19 affected brain function and behaviour. It was discovered that the enzyme was found in the brain of the mouse fetus, which developed differently to that of normal mice. The behaviour of the mice was then examined using a battery of four behavioural tests.

"We found behavioural changes indicating anxiety and a higher stress sensitivity," says research group leader Magnus Ingelman-Sundberg from the Department of Physiology and Pharmacology. "These findings can tell us more about the genetic determinants of anxiety and the transgenic mice can hopefully be used to develop new anxiolytic drugs."

The expression of CYP2C19 in the fetus produced adult mice that had a smaller, stress-hypersensitive hippocampus, an area of the brain essential to learning and memory, adaption and sensitivity to stress and emotional response. A dysfunctional hippocampus in humans is thought to play an important part in the development of both depression and anxiety disorders.

In an earlier study on twins conducted with epidemiologists from Karolinska Institutet, the group observed that individuals lacking the CYP2C19 enzyme display a less depressed base state, a finding that is supported in principle by the present study on mice. The researchers now plan to study what effects genetic variations of CYP2C19 have on the development of the human brain.

"If we can see similar changes in humans, it would improve our understanding of how changes in the developing fetal brain can increase the risk of depression and anxiety disorders later in life," says Anna Persson, in whose doctoral project the study is included.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our anxiety / stress section for the latest news on this subject.

The study was financed by grants from the Swedish Brain Fund, the Torsten and Ragnar Söderberg Foundations, the Swedish Research Council and the Swedish Governmental Agency for Innovation Systems (Vinnova).

“Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene”, Anna Persson, Sarah C Sim, Susanne Virding1, Natalia Onishchenko, Gunnar Schulte1, Magnus Ingelman-Sundberg, Molecular Psychiatry, online 23 2013.

Karolinska Institutet

Please use one of the following formats to cite this article in your essay, paper or report:

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Institutet, Karolinska. "High levels of a specific enzyme in mice fetuses linked to anxiety." Medical News Today. MediLexicon, Intl., 25 Jul. 2013. Web.
26 Jul. 2013. APA

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'High levels of a specific enzyme in mice fetuses linked to anxiety'

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam). We reserve the right to amend opinions where we deem necessary.

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For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



View the original article here

Wednesday, 24 July 2013

Health Tips & Info : 5 Ways to Boost Your Energy Levels.


Energy is essential in this sleep-deprived, high-speed, modern world. Here are 5 simple ways to recharge your batteries and increase productivity and energy levels. If your energy reserves are running low, consider implementing a few of these recommendations over the next few weeks and see how you feel:Getting the right amount of sleep at the right times is critical to staying energized during the day. Eliminate as much light as possible from your bedroom as light interferes with the body’s circadian rhythm thereby interfering with sleep. Avoid napping during the day especially in the late afternoon.2. Get your body moving – exercise.Implement at least 20 minutes of cardio exercise at least 4 times a week. By expending energy on a regular basis, you actually boost your energy levels. Do it regularly but do not push yourself to the point of exhaustion.Evaluate your to-do lists and list down your priorities. Get rid of the less important items. Schedule leisure time for yourself. Stress from any source is an energy zapper, and will have an adverse impact on your general health.4. Eat small but frequent meals.By maintaining a steady supply of nutrients to your body, you increase your long-term energy levels. Incorporate proteins, wholegrains, high-fibre vegetables and nuts into your diet to maintain balanced blood sugar levels. Also, make sure your bigger meals are in the middle of the day rather than at night.5. Cut out energy zappers from your diet.Fluctuations in blood sugar can cause plummeting energy levels. Decrease or cut out refined sugars from your diet. Caffeine intake should also be limited to the mornings. Overuse of caffeine especially in the afternoons will lower energy levels after they give you an initial kick.

View the original article here