Mice experience therapeutic changes in glioma after transplantation of neural stem cells

Main Category: Neurology / Neuroscience
Also Included In: Cancer / Oncology;  Stem Cell Research
Article Date: 15 Aug 2013 - 0:00 PDT Current ratings for:
Mice experience therapeutic changes in glioma after transplantation of neural stem cells

Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and proliferation; however, the mechanism remains unclear.

Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma.

Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis.

To investigate the mechanism of glioblastoma treatment by neural stem cell trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, Hua Li and team from the 476 Hospital of Chinese PLA observed Raf-1, Erk and Bcl-2 protein expression as well as Caspase-3 protein expression.

The researchers found that transplantation of neural stem cells could inhibit the abnormal activation of Ras/Raf/Mek/Erk signaling, thus promoting apoptosis and potentially treating glioma.

These findings are published in Neural Regeneration Research (Vol. 8, No. 19, 2013).

Article: " Apoptosis in glioma-bearing rats after neural stem cell transplantation " by Hua Li1, Zhenjun Chen1, Shaopeng Zhou2 (1 Department of Neurology, the 476 Hospital of Chinese PLA, Fuzhou 350002, Fujian Province, China; 2 Department of Anesthesiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China)

Li H, Chen ZJ, Zhou SP. Apoptosis in glioma-bearing rats after neural stem cell transplantation. Neural Regen Res. 2013;8(19):1793-1802. doi:10.3969/j.issn.1673-5374.2013.19.007

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Taste preference changes in different life stages of rats

Main Category: Seniors / Aging
Also Included In: Nutrition / Diet
Article Date: 02 Aug 2013 - 0:00 PDT Current ratings for:
Taste preference changes in different life stages of rats

Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, found that aging elicits changes in taste preferences and that such changes appear to be independent of taste nerve activity.

In humans and animals aging decreases dietary and energy requirements and it is generally believed that reduced consumption is related to alterations in taste preference. However, the mechanisms underlying an age-induced shift in taste preference remain unclear. Thus, the researchers investigated differences in fluid intake and taste nerve responses across different age groups of rats.

The researchers initially measured the intake of sweet, salty, umami, sour or bitter taste solutions in 5 age groups; juvenile, young-adult, adult, middle-aged and old-aged male rats. The result showed that older animals exhibit a decreased preference for sweet and umami taste and a reduced aversion to bitter taste.

Additional behavioral studies examined whether aging alters taste thresholds by measuring the consumption of simultaneously presented high- and low-concentrated taste solutions. This work revealed that taste sensitivity is lower in older rats.

To elucidate the neural mechanisms of such age-related changes in taste preference and sensitivity, electrophysiological experiments examined taste response characteristics of chorda tympani nerves. These nerves mediate gustatory information from the tongue to the brainstem. The researchers observed no significant differences in activity of the chorda tympani nerves by taste stimuli across the different age groups.

Overall, these behavioral and electrophysiological studies demonstrate that age-related changes in taste preference and sensitivity are independent of the peripheral gustatory system.

The lead author of the study, Chizuko Inui-Yamamoto, Ph.D. states, "To our knowledge, this is the first report demonstrating a reduced aversion to bitter taste in aged rats." She comments, "We had expected that these changes were due to the peripheral taste system." However, differences in electrophysiological recording of taste responses of the chorda tympani nerves across age groups were not observed. "Our studies showed that aging elicited no changes in transmission of taste information from the tongue to the central nervous system. Thus, our future work will investigate the role of the central nervous system in mediating age-induced changes in taste preference", says Inui-Yamamoto.

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This work was supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (B), Grant Number 23792136.

Lead Author: Chizuko Inui-Yamamoto, Dept. of Oral Anatomy, Osaka Dental University

Co-Authors: Takashi Yamamoto, Katsura Ueda, Michiko Nakatsuka, Chunying An, Shunji Kumabe, Yasutomo Iwai

Society for the Study of Ingestive Behavior

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