Also Included In: Cancer / Oncology; Stem Cell Research
Article Date: 15 Aug 2013 - 0:00 PDT Current ratings for:
Mice experience therapeutic changes in glioma after transplantation of neural stem cells
Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and proliferation; however, the mechanism remains unclear.
Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma.
Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis.
To investigate the mechanism of glioblastoma treatment by neural stem cell trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, Hua Li and team from the 476 Hospital of Chinese PLA observed Raf-1, Erk and Bcl-2 protein expression as well as Caspase-3 protein expression.
The researchers found that transplantation of neural stem cells could inhibit the abnormal activation of Ras/Raf/Mek/Erk signaling, thus promoting apoptosis and potentially treating glioma.
These findings are published in Neural Regeneration Research (Vol. 8, No. 19, 2013).
Article: " Apoptosis in glioma-bearing rats after neural stem cell transplantation " by Hua Li1, Zhenjun Chen1, Shaopeng Zhou2 (1 Department of Neurology, the 476 Hospital of Chinese PLA, Fuzhou 350002, Fujian Province, China; 2 Department of Anesthesiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China)
Li H, Chen ZJ, Zhou SP. Apoptosis in glioma-bearing rats after neural stem cell transplantation. Neural Regen Res. 2013;8(19):1793-1802. doi:10.3969/j.issn.1673-5374.2013.19.007
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15 Aug. 2013.
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'Mice experience therapeutic changes in glioma after transplantation of neural stem cells'
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