Showing posts with label Predict. Show all posts
Showing posts with label Predict. Show all posts

Monday, 19 August 2013

Protein biomarkers identified that predict time to ovarian cancer recurrence

Main Category: Ovarian Cancer
Article Date: 19 Aug 2013 - 0:00 PDT Current ratings for:
Protein biomarkers identified that predict time to ovarian cancer recurrence
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Ovarian cancer often remains undetected until it is at an advanced stage. Despite positive responses to initial treatment, many patients are at risk of tumor recurrence. A multitude of genetic markers have been implicated in ovarian cancer prognosis. However, the genetic testing required is not practical or affordable in a clinical setting.

In this issue of the Journal of Clinical Investigation, Roel Verchaak and colleagues at the MD Anderson Cancer Center identify protein biomarkers that are predictive for time of ovarian cancer recurrence and develop a PRotein-driven index of OVARian cancer (PROVAR).

Using PROVAR, the authors were able to discriminate between patients with high and low risk of cancer recurrence, as well as short-term and long-term survival prognosis. In combination with genetic diagnosis, analysis of protein biomarkers may be useful in predicting outcome and determining a treatment plan for ovarian cancer patients.

TITLE: Predicting Time to Ovarian Carcinoma Recurrence Using Protein Markers

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our ovarian cancer section for the latest news on this subject.

J Clin Invest. doi:10.1172/JCI68509.

Journal of Clinical Investigation

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Vitamin D-related 'molecular switches' predict childhood bone mass

Main Category: Bones / Orthopedics
Also Included In: Nutrition / Diet;  Pregnancy / Obstetrics
Article Date: 19 Aug 2013 - 1:00 PDT Current ratings for:
Vitamin D-related 'molecular switches' predict childhood bone mass
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Researchers at the MRC Lifecourse Epidemiology Unit, University of Southampton, have demonstrated that the degree to which a gene related to vitamin D action is switched on or off, when measured at birth, predicts bone density of the child at four years of age.

In the study, 230 boys and girls were assessed at 4 years as part of the Southampton Women's Survey (SWS), a large ongoing mother-offspring cohort. The children visited the Osteoporosis Centre at Southampton General Hospital for measurement of their bone size and density using a DXA scanner. The researchers were able to measure the extent to which a particular gene, RXRA, is switched on or off by measuring epigenetic marks on the DNA sequence of the gene in cells taken from umbilical cord tissue which had been collected at birth. They found that the less marking (which usually means greater gene activity), at birth, the greater the bone density of the child at four years old. Furthermore, one of the epigenetic marks was related to the mother's blood vitamin D concentrations in late pregnancy.

Dr Nicholas Harvey, Senior Lecturer at the MRC Lifecourse Epidemiology Unit, University of Southampton, who led this project said, "RXRA is essential for the action of vitamin D and several other hormones; taken together with the relationship we found between mothers' vitamin D levels and RXRA marking, this study provides further support for the potential importance of vitamin D in pregnancy. We are now testing whether mothers should be supplemented with vitamin D in pregnancy in a randomised controlled trial, the MAVIDOS Maternal Vitamin D Osteoporosis Study, which will report early next year."

Professor Cooper, Professor of Rheumatology and Director of the MRC Lifecourse Epidemiology Unit, University of Southampton and who oversaw this work, added "This study forms part of a larger programme of research at the MRC Lifecourse Epidemiology Unit and University of Southampton in which we are seeking to understand how factors such as diet and lifestyle in the mother during pregnancy, and of the child in early life, influence a child's body composition and bone development. This work should help us to design interventions aimed at optimising body composition in childhood and later adulthood and thus improve the health of future generations".

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our bones / orthopedics section for the latest news on this subject.

Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.

Harvey NC, Sheppard A, Godfrey KM, McLean C, Garratt E, Ntani G, Davies L, Murray R, Inskip HM, Gluckman PD, Hanson MA, Lillycrop KA, Cooper C. J Bone Miner Res. 2013 Aug 1. DOI: 10.1002/jbmr.2056. [Epub ahead of print]

International Osteoporosis Foundation

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Monday, 5 August 2013

The 4-point test to predict death risk from C. difficile

Main Category: Infectious Diseases / Bacteria / Viruses
Article Date: 05 Aug 2013 - 1:00 PDT Current ratings for:
The 4-point test to predict death risk from C. difficile
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A Clostridium difficile (C. diff) infection is one that can affect the digestive system and most commonly affects people staying in hospital. It is not generally a problem for healthy people but may infect those on antibiotics with an imbalance of 'good bacteria' in the gut.

A research paper published on the 2nd August 2013, in BMC Infectious Diseases has for the first time identified a unique four-point test using easily measurable clinical variables which can be used to accurately predict the death risk to patients from C. diff. Accurate prediction means that those patients at risk can be managed accordingly by the clinical team.

There were 17,414 reported cases in England in 2011 and C. diff related deaths accounted for 1.1 per cent of all deaths in England and Wales between 2006 and 2010. Patients over the age of 65 have particular risk of dying from a C. diff infection. Of those, 20 per cent are likely to have a recurrence of infection once antibiotics are withdrawn, and there is growing concern regarding the increasing number of C. diff strains resistant to drug therapies.

The research team behind the study are from the University of Exeter and the Royal Devon & Exeter NHS Foundation Trust (RD&E) and are supported by the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care in the South West Peninsula (NIHR PenCLAHRC).

Joint lead author of the study was Dr. Steve Michell, Senior Lecturer in Molecular Microbiology at the University of Exeter. He said: "Our findings are exciting because they identify a simple, accurate and robust method to identify those patients who are at risk of dying from a C. diff infection. The clinical variables identified are easily measurable, using tests that are commonly carried out in hospital. The results of our study strengthen the evidence for establishing the use of this rule in clinical settings: the benefits to patient well-being, the efficient management of infection in hospital and potential savings to the NHS and other health services around the world, would be immense."

He added: "Our thanks go to colleagues at the RD&E and their patients for their involvement in this study."

The study analysed the clinical notes of 213 patients who had been transferred to the RD&E's specialised C. diff ward between 2007 and 2009. The RD&E's C. diff rate was below the national average during this timescale.

Analysis of the clinical notes, wider information gathered while the patients were in hospital and a follow-up a minimum of 30-days post-discharge, was used by the research team to identify the four points of the test.

These include:

serum albumin levels (protein in blood plasma)respiratory rateC-reactive protein (a protein found in blood, the levels of which rise in inflammation)and white cell count.

A simple four variable prediction rule was devised based on acceptable thresholds for the results of each test.

The rule's comparative simplicity, using fewer variables than those proscribed by other studies, means that it could be used by non-specialists when assessing patients within or around 48 hours of diagnosis. This in turn means that more clinicians could carry out assessments, with more patients assessed and management interventions put in place.

Dr. Ray Sheridan, Consultant Physician at the RD&E, said: "Patients with C. difficile are often much sicker than they might first look. They generally have a weak immune system and are being more prone to infections. Consequently, they don't generate the same immune response as healthier people would. This means that they don't always have the outward signs of infection; for example, they may have a severe infection but won't have a temperature.

"This makes it difficult for non-specialists to recognise how ill patients are and when to start the right treatment. It's important to get the treatment: too much treatment may see new antibiotic resistant strains emerge; too little and patients might die. There are also cost implications. Some of the more intensive treatments need to be really tailored to individual patients and some treatments aren't always very nice to have.

He added: "This really simple and quick tool, which any junior doctor could use in the middle of the night quickly and easily, flags up those who need a speedy and intensive treatment regime or more senior help. The quicker we get on with the right treatment for the right patient the better their chances of recovery are. This is a tool that should be used in every hospital in the UK as soon as possible: if we did so we would save more lives."

He said: "This study a great example of universities and hospitals working together for direct patient benefit."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our infectious diseases / bacteria / viruses section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

MLA

University of Exeter. "The 4-point test to predict death risk from C. difficile." Medical News Today. MediLexicon, Intl., 5 Aug. 2013. Web.
5 Aug. 2013. APA

Please note: If no author information is provided, the source is cited instead.


'The 4-point test to predict death risk from C. difficile'

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Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



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Thursday, 25 July 2013

CombiMatrix - Can We Predict A Bright Future?

CombiMatrix - Can We Predict A Bright Future? - Seeking Alpha (function(_,e,rr,s){_errs=[s];var c=_.onerror;_.onerror=function(){var a=arguments;_errs.push(a); c&&c.apply(this,a)};var b=function(){var c=e.createElement(rr),b=e.getElementsByTagName(rr)[0]; c.src="//beacon.errorception.com/"+s+".js";c.async=!0;b.parentNode.insertBefore(c,b)}; _.addEventListener?_.addEventListener("load",b,!1):_.attachEvent("onload",b)}) (window,document,"script","4ffae9d6f05d1da630000008"); if (SA.Data && SA.Data.Cache) { var adata = SA.Data.Cache.get('campaign_content'); } var ms_slug = ''; var article_dashboards = '@investing-ideas@sectors@'; var article_sectors_themes = '@long-ideas@small-cap-insight@us@biotechnology@healthcare@article@'; var ratings_hash={}; var ARTICLE_ID = 1568252; var ARTICLE_TYPE = "standard"; var ARTICLE_LOCK = ""; var author_slug = "spencer-osborne"; var pticker_for_ads = "cbmx"; var lock_comments = false; var machine_cookie = readCookie('machine_cookie'); var middle_version = ABTest.identity%10; try { window.sessionStorage.setItem("/article/"+ARTICLE_ID, '1'); } catch (error) {}var mone_article_tags = "{arna,cbmx};;;{healthcare};;;{long-ideas,small-cap-insight,us,biotechnology,sa-exclusive};;;{spencer-osborne}"var ord = Math.floor(Math.random()*1000000000);Seeking Alpha Seeking Alpha Portfolio App for iPad Finance (1) var ipadData; SeekingAlpha.Initializer.AddAfterLoad(function(){ if (SA.Utils.Env.isIPad && !/3/.test(SA.Data.Cookies.get("user_devices"))){ Mone.event("ipad_promotion_top","top_ipad_banner_large","ipad_promotion_displayed"); ipadData = new SA.Data.iPad(); ipadData.instanceName = "ipadData"; var responseHandler = new Object(); responseHandler.handleResponse = function(data){ if (!data.averageUserRating) return; var stars = data.averageUserRating Home | Portfolio | Market Currents | Investing Ideas | Dividends & Income | ETFs | Macro View | ALERTS | PRO   This article was sent to 573 people who get email alerts on  . Which cover: new articles | breaking news | earnings results | dividend announcements Get email alerts on   » This article was sent to 319,665 people who get the Investing Ideas newsletter. Get the Investing Ideas newsletter » Comments () This article has  comments. To read them or add your own, click here. Download the Free Seeking Alpha Portfolio App Now! The #1 Portfolio App is Now on iPad! Get instant notifications & never miss a critical update on your stocks! Which Seeking Alpha App is best for you? Seeking Alpha Portfolio Tech Investor ETF investor Energy Investor Email me a link to open from my phone: Continue CombiMatrix - Can We Predict A Bright Future? Jul 24 2013, 13:59 by: Spencer Osborne |  about: CBMX (CombiMatrix Corporation), includes: ARNA

(Editors' Note: This article discusses a micro-cap stock. Please be aware of the risks associated with these stocks.)

Taking a small test and having your future health outlined for you may seem like science fiction, but the ability to assess human health and potential for disease is getting to that point, if not already there. For some the concept may not seem comforting, but for others, knowing that a potential exists will enable fast and early treatment, thus avoiding a terrible fate that might have come.

CombiMatrix (CBMX) is a company that conducts DNA-based genomic testing services in the areas of Prenatal and Pediatric developmental disorders and Oncology. The company carries a $12 million dollar market cap and has a 52 week high of an impressive $14.14 with a 52 week low of $1.40. CombiMatrix currently trades at $3.33. At the moment this stock is highly speculative, highly volatile, and full of potential. The trick is gauging whether or not that potential can turn into something much bigger.

The Potential

In order to gauge the potential of this company we must first understand exactly what it does. We must then determine if there is a market for it, and lastly what the size of that market could be. We want to see if growth is possible, where finances stand, and how the company can derive revenue.

CombiMatrix turns discoveries in human genetics into diagnostic, prognostic and predictive tests that inform physicians, patients and families about specific diseases and clinical manifestations that previously went undetected by older technologies. The theory here is that a predisposition to certain conditions or diseases can be determined on a much more scientific level now. This offers a degree of accuracy that until now was based more on supposition and a look into "family history". In the past you might hear statements such as, "grandpa had high cholesterol, dad had high cholesterol, so I think I will have high cholesterol." Sometime a patient would act on that information and try to maintain a healthy lifestyle and diet that would better his chances of avoiding high cholesterol. However, and perhaps more often, people might take the stance that "it wont happen to me" only to realize too late that they now have high cholesterol and need medicine to deal with the issue. The concept here is predicting for the purpose of treating before the fact.

CombiMatrix is an industry leader in microarray-based clinical testing. The company employs a core team of array CGH-pioneering physicians, scientists and technicians to maintain and evolve that leadership role. CombiMarix is a growing company, That presents a world of opportunity, but also inherent challenges. Keeping this core team in tact will be an important factor in the success of this company. By example, CombiMatrix recently received the recommendation of the American College of Medical Genetics (ACMG) which positioned its DNAarray™ testing as a first line option for the detection and clarification of prevalent developmental disorders such as Autism. Autism is seeing the number of incidents rise substantially over the last decade. While there is still a lot of debate about the reasons for a rise in Autism, there is also a need to be able to diagnose early so that families can work on preparation and proper treatment options. The value of diagnosis and detection is massive.

Over the past six years the predictive testing in oncology has been a critical path item for CombiMatrix. The company has established itself as a sector leader in the implementation of clinical genomic profiling services for hematological malignancies and solid tumors. Certainly no one want to hear that they have cancer. However, if diagnostic testing can give a patient and physician a better understanding of the odds of cancer, that patient and doctor can make the necessary changes to perhaps create changes that do not allow the odds to increase. For patients already diagnosed, the DNAArray tests can give a better understanding of treatment options.

In theory the diagnostic technologies can have even broader capabilities as time passes. As healthcare shifts from a reactionary stance to a more proactive approach, testing early can become beneficial to patient, doctor, as well as insurer. While there are certainly privacy issues that may concern people, there still exists the tried and true doctor/patient confidentiality as a foundation for how medical care will continue.

What Is Happening Now

By all appearances CombiMatrix looks to be a company that is making moves to grow and expand. The company does have challenges. It has fallen below some Nasdaq listing requirements, and at the moment must supply the necessary documentation by August 20th to correct that matter. Other concerns I have are convertible Series C stock and warrants. There are 2,400 shares of Series C Stock outstanding, which are convertible into an aggregate of 839,870 shares of Common Stock at a conversion price of $2.85759. There is a set of warrants to purchase 491,803 shares of Common Stock at the current exercise price of $3.55 and other warrants outstanding to purchase 491,803 shares of Common Stock at an exercise price of $3.77. Convertibles and warrants are sometimes necessary to obtain financing and liquidity, but they can be dilutive later on, especially if they are in the money. With just over 3 million shares currently outstanding, you can imagine the impact of an additional 1.8 million shares in the float.

With that being said, part of this story is potential and business moves that are accretive to the company. In the last month CombiMatrix has been quite busy:

The company has seen substantial growth in prenatal testing subsequent to a study that the company partnered in which was published in the New England Journal of Medicine.CombiMatrix was selected by Pathology, Inc., as the exclusive source for POC testing used in assessing potential and reasons for miscarriages. The state of New York has also approved the Combimatrix tests. This is a fast growing, revenue generating segment of the CombiMatrix business. It appears that this will be one of the core revenue generators for the company.The company inked an impressive deal with Blue Sheild of California for a wide range of testing. Blue shield covers 3 million lives, bringing the total insurance deals to over 60 million lives. This represents about 20% of the population, which leaves a lot of room for growth. A key element of success for CombiMatrix is in insurance, The more insurance companies that come on board, the more the services of CombiMatrix will be utilized by patients and physicians.

Perhaps the most important move that CombiMatrix has made in the past month is appoiting Robert Hoffman to its Board of Directors. Hoffman is a seasoned professional in the biotech space and is currently the Chief Financial Officer at Arena Pharmaceuticals (ARNA). Arena recently launched an anti-obesity called Belviq with marketing partner Eisai. The experience that Hoffman can bring to the table is second to none. Hoffman was an integral part of a company that developed a technology, secured financing, developed a product from that technology, secured a partner to market the product, and essentially was an architect in the inner workings of taking Arena from a concept to a company with a $2 billion dollar market cap and one of only two anti-obesity drugs to gain FDA approval in the last decade. Essentially, the path that Hoffman just navigated down is the path that CombiMatrix want to follow. Hoffman will bring insight to CombiMatrix at a critical juncture in its corporate story.

While there are still substantial risks with an investment in CombiMatrix, there is also substantial potential. The company will have several hurdles to navigate, but with good management and an experienced Board of Directors, the company is making some good moves early in the process. In my opinion this is an equity that saw a run, saw a correction, and has settled to a great starting point. At $3.33 it is worth some serious consideration.

Source: CombiMatrix - Can We Predict A Bright Future?

Disclosure: I am long ARNA. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. (More...)

Additional disclosure: I have no position in CombiMatrix

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