Also Included In: Genetics; Pediatrics / Children's Health
Article Date: 19 Aug 2013 - 0:00 PDT Current ratings for:
Cell cycle-related genes in the pathogenesis of neural tube defects
In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube.
Preliminary studies by Xinjun Li and colleagues from Deyang People's Hospital have identified several genes involved in the development of neural tube defects.
Their recent study published in Neural Regeneration Research (Vol. 8, No. 20, 2013) established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats. Gene chip hybridization analysis showed that genes related to the cell cycle and apoptosis, signal transduction, transcription and translation regulation, energy and metabolism, heat shock, and matrix and cytoskeletal proteins were all involved in the formation of developmental neural tube defects. Among these, cell cycle-related genes were predominant. Retinoic acid treatment caused differential expression of three cell cycle-related genes p57kip2, Cdk5 and Spin, the expression levels of which were downregulated by retinoic acid and upregulated during normal neural tube formation.
The results of this study indicate that cell cycle-related genes play an important role in the formation of neural tube defects. P57kip2, Cdk5 and Spin may be critical genes in the pathogenesis of neural tube defects.
Article: " Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects," by Xinjun Li1, Zhong Yang2, Yi Zeng3, Hong Xu1, Hongli Li2, Yangyun Han1, Xiaodong Long1, Chao You4 (1 Department of Neurosurgery, Deyang People's Hospital, Deyang 618000, Sichuan Province, China; 2 Department of Neurobiology, the Third Military Medical University of Chinese PLA, Chongqing 400038, China; 3 Department of Neurosurgery, Sichuan Provincial People's Hospital, Chengdu 610041, Sichuan Province, China)
Li XJ, Yang Z, Zeng Y, Xu H, Li HL, Han YY, Long XD, You C. Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects. Neural Regen Res. 2013;8(20):1863-1871. doi:10.3969/j.issn.1673-5374.2013.20.005
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.Visit our neurology / neuroscience section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:
MLA
19 Aug. 2013.
Please note: If no author information is provided, the source is cited instead.
'Cell cycle-related genes in the pathogenesis of neural tube defects'
Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.
If you write about specific medications or operations, please do not name health care professionals by name.
All opinions are moderated before being included (to stop spam). We reserve the right to amend opinions where we deem necessary.
Contact Our News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
No comments:
Post a Comment